Parkinson's disease, cognition and aging Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment
Identifieur interne : 002084 ( Main/Exploration ); précédent : 002083; suivant : 002085Parkinson's disease, cognition and aging Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment
Auteurs : Osamah H. Elwan [Égypte] ; Osamah H. Baradah [Égypte] ; Obsis Madkour [Égypte] ; Hassan Elwan [Égypte] ; Azza A. H. Hassan [Égypte] ; Fadya Elwan [Égypte] ; Mamdouh Mahfouz [Égypte] ; Ann Ali [Égypte] ; Manal Fahmy [Égypte]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1996.
Abstract
Forty-three patients with Parkinson's disease (PD) and thirty-seven normal volunteers were subjected to clinical, neuropsychological, neurophysiological (P300 component of the event-related potentials ERP) and radiological (cranial computerized tomographic scanning CCT) evaluation. Intentional memory was more impaired in PD than in normal controls, more so in the demented group of patients, and was related to enlargement of third ventricular size in CCT. While intentional memory was age related in PD patients, perception was age-related in normal controls. Neither global nor specific cognitive functions were related to duration, severity of parkinsonian motor disability, or depression. However, depression in PD was significantly related to parkinsonian motor disability. P300 latency was more prolonged in PD patients than normal controls. P300 parameters of PD patients were not influenced by age, cognitive functions, duration or severity of motor disability, or depression. The reaction time was the only P300 parameter that was age-related in normal controls. Subcortical atrophy as indicated by CCT was more marked in PD and correlated with age in both patients and controls. Subcortical atrophy was significantly related to cognitive functions in PD but not in normal controls. It was concluded that cognitive impairment in PD could be attributed to complex cognitive changes rather than age. It is a disease process, though not directly related to parkinsonian motor disability or depression. PD differed from normal aging as regards the effect of age on the specific cognitive functions, where in PD patients, age was related to intentional memory, yet in normal controls, it was related to perception. Intentional memory deterioration was found to be specific of PD, being related to subcortical atrophy as well as being more pronounced in the demented group of patients.
Url:
DOI: 10.1016/S0022-510X(96)00161-X
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Parkinson's disease, cognition and aging Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment</title>
<author><name sortKey="Elwan, Osamah H" sort="Elwan, Osamah H" uniqKey="Elwan O" first="Osamah H." last="Elwan">Osamah H. Elwan</name>
</author>
<author><name sortKey="Baradah, Osamah H" sort="Baradah, Osamah H" uniqKey="Baradah O" first="Osamah H." last="Baradah">Osamah H. Baradah</name>
</author>
<author><name sortKey="Madkour, Obsis" sort="Madkour, Obsis" uniqKey="Madkour O" first="Obsis" last="Madkour">Obsis Madkour</name>
</author>
<author><name sortKey="Elwan, Hassan" sort="Elwan, Hassan" uniqKey="Elwan H" first="Hassan" last="Elwan">Hassan Elwan</name>
</author>
<author><name sortKey="Hassan, Azza A H" sort="Hassan, Azza A H" uniqKey="Hassan A" first="Azza A. H." last="Hassan">Azza A. H. Hassan</name>
</author>
<author><name sortKey="Elwan, Fadya" sort="Elwan, Fadya" uniqKey="Elwan F" first="Fadya" last="Elwan">Fadya Elwan</name>
</author>
<author><name sortKey="Mahfouz, Mamdouh" sort="Mahfouz, Mamdouh" uniqKey="Mahfouz M" first="Mamdouh" last="Mahfouz">Mamdouh Mahfouz</name>
</author>
<author><name sortKey="Ali, Ann" sort="Ali, Ann" uniqKey="Ali A" first="Ann" last="Ali">Ann Ali</name>
</author>
<author><name sortKey="Fahmy, Manal" sort="Fahmy, Manal" uniqKey="Fahmy M" first="Manal" last="Fahmy">Manal Fahmy</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:CDCB2F940DB8845497440E10AB7C7DE7B24B7DA6</idno>
<date when="1996" year="1996">1996</date>
<idno type="doi">10.1016/S0022-510X(96)00161-X</idno>
<idno type="url">https://api.istex.fr/document/CDCB2F940DB8845497440E10AB7C7DE7B24B7DA6/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001A46</idno>
<idno type="wicri:Area/Main/Curation">001788</idno>
<idno type="wicri:Area/Main/Exploration">002084</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Parkinson's disease, cognition and aging Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment</title>
<author><name sortKey="Elwan, Osamah H" sort="Elwan, Osamah H" uniqKey="Elwan O" first="Osamah H." last="Elwan">Osamah H. Elwan</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Neurology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Égypte</country>
</affiliation>
</author>
<author><name sortKey="Baradah, Osamah H" sort="Baradah, Osamah H" uniqKey="Baradah O" first="Osamah H." last="Baradah">Osamah H. Baradah</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Neurology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Madkour, Obsis" sort="Madkour, Obsis" uniqKey="Madkour O" first="Obsis" last="Madkour">Obsis Madkour</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Neurophysiology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elwan, Hassan" sort="Elwan, Hassan" uniqKey="Elwan H" first="Hassan" last="Elwan">Hassan Elwan</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Neurology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hassan, Azza A H" sort="Hassan, Azza A H" uniqKey="Hassan A" first="Azza A. H." last="Hassan">Azza A. H. Hassan</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Neurology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elwan, Fadya" sort="Elwan, Fadya" uniqKey="Elwan F" first="Fadya" last="Elwan">Fadya Elwan</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Psychology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mahfouz, Mamdouh" sort="Mahfouz, Mamdouh" uniqKey="Mahfouz M" first="Mamdouh" last="Mahfouz">Mamdouh Mahfouz</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Radiology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ali, Ann" sort="Ali, Ann" uniqKey="Ali A" first="Ann" last="Ali">Ann Ali</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Neurophysiology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fahmy, Manal" sort="Fahmy, Manal" uniqKey="Fahmy M" first="Manal" last="Fahmy">Manal Fahmy</name>
<affiliation wicri:level="1"><country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Neurology, Cairo University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of the Neurological Sciences</title>
<title level="j" type="abbrev">JNS</title>
<idno type="ISSN">0022-510X</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1996">1996</date>
<biblScope unit="volume">143</biblScope>
<biblScope unit="issue">1–2</biblScope>
<biblScope unit="page" from="64">64</biblScope>
<biblScope unit="page" to="71">71</biblScope>
</imprint>
<idno type="ISSN">0022-510X</idno>
</series>
<idno type="istex">CDCB2F940DB8845497440E10AB7C7DE7B24B7DA6</idno>
<idno type="DOI">10.1016/S0022-510X(96)00161-X</idno>
<idno type="PII">S0022-510X(96)00161-X</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-510X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Forty-three patients with Parkinson's disease (PD) and thirty-seven normal volunteers were subjected to clinical, neuropsychological, neurophysiological (P300 component of the event-related potentials ERP) and radiological (cranial computerized tomographic scanning CCT) evaluation. Intentional memory was more impaired in PD than in normal controls, more so in the demented group of patients, and was related to enlargement of third ventricular size in CCT. While intentional memory was age related in PD patients, perception was age-related in normal controls. Neither global nor specific cognitive functions were related to duration, severity of parkinsonian motor disability, or depression. However, depression in PD was significantly related to parkinsonian motor disability. P300 latency was more prolonged in PD patients than normal controls. P300 parameters of PD patients were not influenced by age, cognitive functions, duration or severity of motor disability, or depression. The reaction time was the only P300 parameter that was age-related in normal controls. Subcortical atrophy as indicated by CCT was more marked in PD and correlated with age in both patients and controls. Subcortical atrophy was significantly related to cognitive functions in PD but not in normal controls. It was concluded that cognitive impairment in PD could be attributed to complex cognitive changes rather than age. It is a disease process, though not directly related to parkinsonian motor disability or depression. PD differed from normal aging as regards the effect of age on the specific cognitive functions, where in PD patients, age was related to intentional memory, yet in normal controls, it was related to perception. Intentional memory deterioration was found to be specific of PD, being related to subcortical atrophy as well as being more pronounced in the demented group of patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Égypte</li>
</country>
</list>
<tree><country name="Égypte"><noRegion><name sortKey="Elwan, Osamah H" sort="Elwan, Osamah H" uniqKey="Elwan O" first="Osamah H." last="Elwan">Osamah H. Elwan</name>
</noRegion>
<name sortKey="Ali, Ann" sort="Ali, Ann" uniqKey="Ali A" first="Ann" last="Ali">Ann Ali</name>
<name sortKey="Baradah, Osamah H" sort="Baradah, Osamah H" uniqKey="Baradah O" first="Osamah H." last="Baradah">Osamah H. Baradah</name>
<name sortKey="Elwan, Fadya" sort="Elwan, Fadya" uniqKey="Elwan F" first="Fadya" last="Elwan">Fadya Elwan</name>
<name sortKey="Elwan, Hassan" sort="Elwan, Hassan" uniqKey="Elwan H" first="Hassan" last="Elwan">Hassan Elwan</name>
<name sortKey="Elwan, Osamah H" sort="Elwan, Osamah H" uniqKey="Elwan O" first="Osamah H." last="Elwan">Osamah H. Elwan</name>
<name sortKey="Fahmy, Manal" sort="Fahmy, Manal" uniqKey="Fahmy M" first="Manal" last="Fahmy">Manal Fahmy</name>
<name sortKey="Hassan, Azza A H" sort="Hassan, Azza A H" uniqKey="Hassan A" first="Azza A. H." last="Hassan">Azza A. H. Hassan</name>
<name sortKey="Madkour, Obsis" sort="Madkour, Obsis" uniqKey="Madkour O" first="Obsis" last="Madkour">Obsis Madkour</name>
<name sortKey="Mahfouz, Mamdouh" sort="Mahfouz, Mamdouh" uniqKey="Mahfouz M" first="Mamdouh" last="Mahfouz">Mamdouh Mahfouz</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002084 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002084 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:CDCB2F940DB8845497440E10AB7C7DE7B24B7DA6 |texte= Parkinson's disease, cognition and aging Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment }}
This area was generated with Dilib version V0.6.23. |